Enhancement of Pulmozyme activity in purulent sputum by combination with poly-aspartic acid or gelsolin
DNase (Pulmozyme) effectiveness in cystic fibrosis treatment is in some cases limited by its inability to access DNA trapped within bundles in highly viscous fluids that also contain actin. Dissociating DNA-containing bundles using actin depolymerizing agents and polyanions has potential to increase DNase efficacy.
Source: Journal of Cystic Fibrosis - Category: Respiratory Medicine Authors: Robert Bucki, Katrina Cruz, Katarzyna Pogoda, Ashley Eggert, LiKang Chin, Marianne Ferrin, Giovanna Imbesi, Denis Hadjiliadis, Paul A. Janmey Tags: Original Article Source Type: research