Cytokine-specific autoantibodies shape the gut microbiome in autoimmune polyendocrine syndrome type 1

Capsule summaryThe gut microbiome in APS-1 patients correlates with gastrointestinal symptoms and cytokine-specific autoantibodies. Administration of L. rhamnosus GG alleviated dysphagia and aerophagia in 5/5 APS-1 patients and balanced abdominal functions in 9/18 patients.

Source: Journal of Allergy and Clinical Immunology - April 2, 2021 Category: Allergy & Immunology Authors: Anders Ø. Petersen, Martta Jokinen, Damian R. Plichta, Gerhard Liebisch, Wolfram Gronwald, Peter J. Oefner, Hera Vlamakis, Daniel C. Chung, Annamari Ranki, Ramnik J. Xavier Source Type: research