Aryl Hydrocarbon Receptor-Interacting Protein (AIP) in the Human Dermis with Aging

AbstractThe goal of the present work was to study the content of aryl hydrocarbon receptor –interacting protein (AIP) in dermal fibroblasts from the age of 20 weeks of fetal development and to the age of 85 years and to determine the significance of AIP for age-related changes in the fibroblast number in the human dermis. AIP and proliferating cell nuclear antigen (PCNA) were revealed i n skin sections with an indirect immunochemical method. The results demonstrated that a proportion of dermal fibroblasts with positive staining for AIP gradually increases from 20 weeks of fetal development to the age of 85 years. The total number and proportion of PCNA-positive fibroblasts in the d ermis decreased with age. The most significant age-related decrease in the total number and PCNA-positive fibroblasts in the dermis was observed from the antenatal period to the age of 40 years. Correlation analysis demonstrated that an age-related decrease in the total fibroblast number and a decre ase in their proliferative activity are significantly associated with an increase in the percentage of fibroblasts with positive staining for AIP. The results suggest that AIP is involved in an age-related decrease in the number and proliferation of fibroblasts in the human dermis.

Source: Advances in Gerontology - January 1, 2021 Category: Geriatrics Source Type: research