Injection Laryngoplasty and Novel Injectable Materials

AbstractPurpose of ReviewGlottic insufficiency (GI) is most often caused by vocal fold atrophy, immobility, hypomobility, or scar. Injection laryngoplasty (IL), the injection of a filler material into the vocal folds to improve glottic closure, has been used to improve clinical outcomes in patients with GI. This paper will provide a review of contemporary practices and injection materials in IL.Recent FindingsMost ILs are now performed in an office setting, through a per oral, transnasal, or percutaneous approach. Today, most short-term injections are performed using carboxymethylcellulose. Most intermediate injections are done with hyaluronic acid gels. Long-term injections are done with autologous fat, calcium hydroxyapatite, or polydimethylsiloxane. Silk-hyaluronic acid is a newer material being used for long-term injections. Novel materials under investigation include fibroblast growth factor and autologous fibroblasts.SummaryWithin the past 15 years, the landscape of injected materials for IL has changed greatly. Newer materials are more similar in composition to native vocal fold tissue and are less likely to migrate from the site of injection and elicit low rates of inflammatory responses.

Source: Current Otorhinolaryngology Reports - March 16, 2021 Category: ENT & OMF Source Type: research