n -Propyl 6-amino-2,6-dideoxy-2,2-difluoro- β- d -glucopyranoside is a good inhibitor for the β-galactosidase from E. coli

AbstractA convenient route has been developed for the synthesis of novel 6-amino-2,2-(or 3,3-difluoro)-2-(or 3),6-dideoxy-hexopyranoses. Biological screening showed these compounds as good inhibitors for several glycosidases. Especiallyn-propyl 6-amino-2,6-dideoxy-2,2-difluoro- β-d-glucopyranoside (8) was an excellent competitive inhibitor for the β-galactosidase fromE. coli holding aKi of 0.50  μM.
Source: Medicinal Chemistry Research - Category: Chemistry Source Type: research