Limb muscle size and contractile function in adults with cystic fibrosis: A systematic review and meta-analysis

The life expectancy of people with cystic fibrosis (CF) has drastically increased over the last decades [1,2]. As people with CF are living longer, there is greater attention directed towards musculoskeletal issues. Impairment in limb muscle is associated with decreased mobility and physical activity in CF [3], which is in turn associated with reduced health-related quality of life [4]. Limb muscle atrophy and muscle weakness are also associated with lower functional capacity [3] and lung function in people with CF [5,6]; and lower lean muscle mass is associated with increased mortality in CF [7], underscoring its clinical importance in people with CF.
Source: Journal of Cystic Fibrosis - Category: Respiratory Medicine Authors: Tags: Original Article Source Type: research