Palladium-catalyzed diastereoselective cross-coupling of two aryl halides < em > via < /em > C-H activation: synthesis of chiral eight-membered nitrogen heterocycles

Chem Commun (Camb). 2021 Feb 23. doi: 10.1039/d1cc00398d. Online ahead of print.ABSTRACTA method for the synthesis of enantiopure eight-membered nitrogen heterocycles has been developed through diastereoselective cross-coupling of 2-iodobiphenyls with 2-bromobenzylamines. The products represent a novel type of chiral scaffold, which feature easy modification and high configurative stability and have the potential to be applied in asymmetric synthesis. Palladacycles that were formed via the C-H activation of 2-iodobiphenyls should act as the intermediates. The reaction provides a new strategy for the synthesis of medium-sized ring compounds.PMID:33621301 | DOI:10.1039/d1cc00398d

Source: Chemical Communications - February 23, 2021 Category: Chemistry Authors: Cang Cheng Xiang Zuo Dongdong Tu Bin Wan Yanghui Zhang Source Type: research