Interleukin-20 exacerbates acute hepatitis and bacterial infection by downregulating I κBζ target genes in hepatocytes

Interleukin-20 (IL-20) and IL-22 belong to the IL-10 family. IL-10 is a well-documented anti-inflammatory cytokine while IL-22 is well-known for its epithelial protection and anti-bacterial function, showing great therapeutic potential for organ damage; but the function of IL-20 remains largely unknown.

Source: Journal of Hepatology - February 17, 2021 Category: Gastroenterology Authors: Yong He, Dechun Feng, Seonghwan Hwang, Bryan Mackowiak, Xiaolin Wang, Xiaogang Xiang, Robim M. Rodrigues, Yaojie Fu, Jing Ma, Tianyi Ren, Yeni Ait-Ahmed, Mingjiang Xu, Suthat Liangpunsakul, Bin Gao Source Type: research