Plasma syndecan-1 is associated with fluid requirements and clinical outcomes in emergency department patients with sepsis

Degradation of the endothelial glycocalyx is recognized as a major part of the pathophysiology of sepsis. Previous clinical studies, mostly conducted in intensive care settings, showed associations between glycocalyx shedding and clinical outcomes. We aimed to explore the association of plasma syndecan-1, a marker of glycocalyx degradation, with the subsequent fluid requirements and clinical outcomes of emergency department patients with sepsis.
Source: The American Journal of Emergency Medicine - Category: Emergency Medicine Authors: Source Type: research