Cutaneous marginal zone lymphoma of the nose arising after rhinoplasty with filler injection

AbstractChronic inflammation induced by infection, autoimmune disorders, and immune reaction against foreign bodies are recognized as causative factors for the development of lymphoma. Here, a case of B cell lymphoma arising after augmentation rhinoplasty with filler injection is reported. A 48-year-old Japanese woman underwent rhinoplasty with filler injection at a cosmetic clinic 10  years ago. She, presently, came with complaints of a nodule at the nasal root. Histologic examination of the biopsy specimen revealed diffuse infiltration of centrocyte-like cells with plasmacytic differentiation in the subcutis and procerus muscle. Immunohistochemistry showed that the tumor cells were CD3−, CD5−, CD10−, CD20+, CD79+, bcl-2+, bcl-10+, IgG+, IgA−, and IgM−. In situ hybridization for Epstein-Barr virus small RNAs was negative. The final diagnosis was extranodal marginal zone lymphoma. This is a case of foreign body-induced carcinogenesis. Various aspects of chronic i nflammation that propel lymphoma development are discussed with their morphology, immunophenotype, and viral association.
Source: Journal of Hematopathology - Category: Pathology Source Type: research