Protein disulphide-isomerase A2 regulated intracellular tissue factor mobilisation in migrating human vascular smooth muscle cells.

In conclusion, we demonstrate that TF is chaperoned by PDIA2 to the HVSMC membrane and to the cell migratory front. Absence of PDIA2 impairs TF intracellular trafficking to its membrane docking favoring its uncontrolled release in microparticles. TF-regulated HVSMC migration and microvessel formation is under the control of the ER-protein PDIA2.
PMID: 25631539 [PubMed - as supplied by publisher]

Source: Thrombosis and Haemostasis - January 29, 2015 Category: Hematology Authors: Peña E, Arderiu G, Badimon L Tags: Thromb Haemost Source Type: research