Role of Proprotein Convertase Subtilisin/Kexin Type 9 in the Pathogenesis of Graves ’ Orbitopathy in Orbital Fibroblasts

ConclusionsPCSK9 plays a significant role in GO. The PCSK9 inhibition attenuated the pro-inflammatory cytokines production, oxidative stress, and fibroblast differentiation into adipocytes. PCSK9 may serve as a therapeutic target and biomarker for GO.
Source: Frontiers in Endocrinology - Category: Endocrinology Source Type: research