G βγ recruits and activates P-Rex1 via two independent binding interfaces.

In conclusion, we reconcile previous findings and propose a mechanistic model of P-Rex1 activation; accordingly, Gβγ recruits P-Rex1 via the Gβγ/PDZ-PDZ interface followed by a second contact involving the Gβγ/DH/PH interface to unleash P-Rex1 RacGEF activity at the plasma membrane. PMID: 33412417 [PubMed - as supplied by publisher]

https://www.ncbi.nlm.nih.gov/pubmed/33412417?dopt=Abstract

Source: Biochemical and Biophysical Research communications - January 4, 2021 Category: Biochemistry Authors: Cervantes-Villagrana RD, Beltrán-Navarro YM, García-Jiménez I, Adame-García SR, Olguín-Olguín A, Reyes-Cruz G, Vázquez-Prado J Tags: Biochem Biophys Res Commun Source Type: research

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