New triazole-bearing gramine derivatives - synthesis, structural analysis and protective effect against oxidative haemolysis.

New triazole-bearing gramine derivatives - synthesis, structural analysis and protective effect against oxidative haemolysis.
Nat Prod Res. 2020 Dec 24;:1-7
Authors: Kozanecka-Okupnik W, Sierakowska A, Berdzik N, Kowalczyk I, Mrówczyńska L, Jasiewicz B
Abstract
The new series of triazole-bearing gramine derivatives were synthesized through a CuAAC procedure. The structures of all newly obtained compounds were confirmed by spectroscopic analysis and DFT methods. The obtained derivatives were screened for their protective potency against oxidative haemolysis induced by free radicals generated from 2,2'-azobis(2-methylpropionamidine) dihydrochloride (AAPH). Our work demonstrates that derivatives with propyl or octyl linker and phthalimide group associated with indole-triazole moiety, which have a folded structure, effectively protect human erythrocytes against oxidative stress-induced haemolysis.
PMID: 33356568 [PubMed - as supplied by publisher]

Source: Natural Product Research - December 24, 2020 Category: Biochemistry Authors: Kozanecka-Okupnik W, Sierakowska A, Berdzik N, Kowalczyk I, Mrówczyńska L, Jasiewicz B Tags: Nat Prod Res Source Type: research