The conformation-specific Hsp90 inhibition interferes with the oncogenic RAF kinase adaptation and triggers premature cellular senescence, hence, acts as a tumor suppressor mechanism

Publication date: Available online 23 December 2020Source: Biochimica et Biophysica Acta (BBA) - Molecular Cell ResearchAuthor(s): Kanugovi Vijayavittal Abhijnya, Amere Subbarao Sreedhar

Source: Biochimica et Biophysica Acta (BBA) Molecular Cell Research - December 23, 2020 Category: Molecular Biology Source Type: research