The complex role of Prostaglandin E2-EP receptor signaling in wound healing.

The complex role of Prostaglandin E2-EP receptor signaling in wound healing.
Am J Physiol Regul Integr Comp Physiol. 2020 Dec 09;:
Authors: Gilman KE, Limesand KH
Abstract
Prostaglandins are critical lipid mediators involved in the wound healing response, with prostaglandin E2 (PGE2) being the most complex and exhibiting the most diverse physiological outputs. PGE2 signals via four G-protein coupled receptors, termed EP-receptors 1-4, that induce distinct signaling pathways upon activation and lead to an array of different outputs. Recent studies examining the role of PGE2 and EP receptor signaling in wound healing following various forms of tissue damage are discussed in this review.
PMID: 33296281 [PubMed - as supplied by publisher]

Source: American Journal of Physiology. Regulatory, Integrative and Comparative Physiology - December 9, 2020 Category: Physiology Authors: Gilman KE, Limesand KH Tags: Am J Physiol Regul Integr Comp Physiol Source Type: research