The great mimicker: a rare presentation of Whipple's disease diagnosed on a gastric biopsy

A 60-year-old gentleman presented with chronic diarrhoea and weight loss. Following an array of investigations, primarily targeting a possible malignancy, gastritis and duodenitis were observed on endoscopy. Gastric and duodenal biopsies showed aggregates of PAS positive macrophages in the lamina propria. Polymerase chain reaction confirmed the presence of Whipple's disease (WD). WD is a rare multisystemic granulomatous infectious disorder, affecting many organ systems but predominantly the gastrointestinal system.
Source: Diagnostic Histopathology - Category: Pathology Authors: Tags: Short Case Source Type: research