Quadriceps muscle weakness and atrophy are associated with a differential Epigenetic Profile in Advanced COPD

Epigenetic mechanisms regulate muscle mass and function in models of muscle dysfunction and atrophy. We assessed whether quadriceps muscle weakness and atrophy are associated with a differential expression profile of epigenetic events in patients with advanced COPD. In vastus lateralis (VL) of sedentary severe COPD patients (n=41), who were further subdivided into those with (n=25) and without (n=16) muscle weakness, and healthy controls (n=19), expression of muscle-enriched microRNAs, histone acetyltransferases (HATs) and deacetylases (HDACs), growth and atrophy signaling markers, total protein and histone acetylation, transcription factors, small ubiquitin-related modifier (SUMO) ligases, and muscle structure were explored. All subjects were clinically evaluated. Compared to controls, in VL of all COPD together and in muscle-weakness patients, expression of miR-1, -206, and -27a, levels of lysine-acetylated proteins and histones, and acetylated histone 3 were increased, while expression of HDAC3, HDAC4, sirtuin-1, IGF-1 were decreased, Akt expression did not differ, follistatin expression was greater, whereas myostatin expression was lower, serum reponse factor (SRF) expression was increased, and fiber size of fast-twitch fibers was significantly reduced. In VL of severe COPD patients with muscle weakness and atrophy, epigenetic events regulate muscle differentiation rather than proliferation, and muscle growth and atrophy signaling, probably as feedback mechanisms to preve...
Source: Clinical Science - Category: Biomedical Science Authors: Source Type: research

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In conclusion, reporting breathlessness as the primary exercise-limiting symptom indicated the presence of distinct lung pathophysiology and symptom perception during exercise in people with COPD.
Source: Respiratory Physiology and Neurobiology - Category: Respiratory Medicine Source Type: research
Initial insights from the Stanford Medicine X COPD Challenge reiterate the power of social media to galvanize communities around healthcare predicaments. Last month, Grace Anne Dorney Koppel and her husband —icon of American news—Ted Koppel, learned that there’s nothing quite like presenting a massive health predicament to the passionate Stanford Medicine X (MedX) community. I’m referring, of course, to the 2019 Stanford Medicine X| CHANGE Educational Grand Challenge on COPD. As noted previously, Symplur joined the Challenge and is providing…ContinuedThe postCOPD,“Our Biggest Challenge&...
Source: Connecting the dots in healthcare social media – Symplur - Category: Information Technology Authors: Tags: Connecting the dots in healthcare social media #MedX COPD design challenge Grace Anne Dorney Koppel Stanford Medicine X Ted Koppel Source Type: blogs
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Source: Drugs.com - Pharma News - Category: Pharmaceuticals Source Type: news
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Source: Drugs.com - Daily MedNews - Category: General Medicine Source Type: news
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Source: Experimental and Therapeutic Medicine - Category: General Medicine Tags: Exp Ther Med Source Type: research
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Source: Jornal Brasileiro de Pneumologia - Category: Respiratory Medicine Source Type: research
ABSTRACT Objective: To compare religious coping (RC) in patients with COPD and healthy individuals, as well as to determine whether RC is associated with demographic characteristics, quality of life, depression, and disease severity in the patients with COPD. Methods: This was a cross-sectional study conducted between 2014 and 2016, involving outpatients with moderate to severe COPD seen at one of two hospitals in Fortaleza, Brazil, as well as gender- and age-matched healthy controls. The Brief RCOPE scale assessed RC in all of the participants. We also evaluated the COPD group patients regarding symptoms, quality of life,...
Source: Jornal Brasileiro de Pneumologia - Category: Respiratory Medicine Source Type: research
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Source: Anaesthesia and intensive care medicine - Category: Anesthesiology Source Type: research
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Source: Infection and Immunity - Category: Infectious Diseases Authors: Tags: Molecular Pathogenesis Source Type: research
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Source: BMC Pulmonary Medicine - Category: Respiratory Medicine Authors: Tags: Research article Source Type: research
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