pH-Dependent peptide bond formation by the selective coupling of α-amino acids in water.

pH-Dependent peptide bond formation by the selective coupling of α-amino acids in water.
Chem Commun (Camb). 2020 Nov 26;:
Authors: Wu LF, Liu Z, Sutherland JD
Abstract
A novel mechanism enabling selective peptide elongation by coupling α-amino acids over other potentially competing prebiotic amines under acidic aqueous condition is suggested. It proceeds via the generation of a carboxylic acid anhydride intermediate with subsequent intramolecular formation of the amide bond.
PMID: 33242043 [PubMed - as supplied by publisher]

Source: Chemical Communications - November 26, 2020 Category: Chemistry Authors: Wu LF, Liu Z, Sutherland JD Tags: Chem Commun (Camb) Source Type: research