Modulation of red blood cell oxygen affinity with a novel allosteric modifier of hemoglobin is additive to the Bohr effect.

CONCLUSION: The Bohr effect is conserved, with ITPP augmenting the decreased oxygen affinity seen with tissue acidosis, while not affecting oxygen affinity in conditions similar to a pulmonary microenvironment.
PMID: 33242840 [PubMed - as supplied by publisher]

Source: Blood Cells, Molecules and Diseases - November 19, 2020 Category: Hematology Authors: Evans BA, Ansari AK, Kamyszek RW, Salvagno M, Welsby J, Fuller M, Welsby I Tags: Blood Cells Mol Dis Source Type: research