The COX-2-derived PGE2 autocrine contributes to bradykinin-induced matrix metalloproteinase-9 expression and astrocytic migration via STAT3 signaling

The matrix metalloproteinase-9 (MMP-9) is up-regulated by several proinflammatory mediators in the central nervous system (CNS) diseases. Increasing reports show that MMP-9 expression is an inflammatory biomar...

Source: Cell Communication and Signaling - November 23, 2020 Category: Molecular Biology Authors: Tsong-Hai Lee, Pei-Shan Liu, Ming-Ming Tsai, Jiun-Liang Chen, Su-Jane Wang and Hsi-Lung Hsieh Tags: Research Source Type: research