Tyrosine 192 within the SH2 domain of the Src-protein tyrosine kinase p56Lck regulates T-cell activation independently of Lck/CD45 interactions

Upon engagement of the T-cell receptor (TCR), the Src-family protein tyrosine kinase p56Lck phosphorylates components of the TCR (e.g. the TCR ζ chains), thereby initiating T-cell activation. The enzymatic acti...

Source: Cell Communication and Signaling - November 23, 2020 Category: Molecular Biology Authors: Matthias K ästle, Camilla Merten, Roland Hartig, Thilo Kaehne, Ardiyanto Liaunardy-Jopeace, Nadine M. Woessner, Wolfgang W. Schamel, John James, Susana Minguet, Luca Simeoni and Burkhart Schraven Tags: Research Source Type: research