Deep eutectic solvent-catalyzed Meyer-Schuster rearrangement of propargylic alcohols under mild and bench reaction conditions.

Deep eutectic solvent-catalyzed Meyer-Schuster rearrangement of propargylic alcohols under mild and bench reaction conditions.
Chem Commun (Camb). 2020 Nov 20;:
Authors: Ríos-Lombardía N, Cicco L, Yamamoto K, Hernández-Fernández JA, Morís F, Capriati V, García-Álvarez J, González-Sabín J
Abstract
The Meyer-Schuster rearrangement of propargylic alcohols into α,β-unsaturated carbonyl compounds has been revisited by setting up an atom-economic process catalyzed by a deep eutectic solvent FeCl3·6H2O/glycerol. Isomerizations take place smoothly, at room temperature, under air and with short reaction times. The unique solubilizing properties of the eutectic mixture enabled the use of a substrate concentration up to 1.0 M with the medium being recycled up to ten runs without any loss of catalytic activity.
PMID: 33215181 [PubMed - as supplied by publisher]

Source: Chemical Communications - November 20, 2020 Category: Chemistry Authors: Ríos-Lombardía N, Cicco L, Yamamoto K, Hernández-Fernández JA, Morís F, Capriati V, García-Álvarez J, González-Sabín J Tags: Chem Commun (Camb) Source Type: research