Dose Assessment Following a 238Pu-contaminated Wound Case with Chelation and Excision.

Dose Assessment Following a 238Pu-contaminated Wound Case with Chelation and Excision.
Health Phys. 2020 Dec;119(6):690-703
Authors: Poudel D, Klumpp JA, Bertelli L, Dumit S, Waters TL
Abstract
The urinary excretion and wound retention data collected after a Pu-contaminated wound were analyzed using Markov Chain Monte Carlo (MCMC) to obtain the posterior distribution of the intakes and doses. An empirical approach was used to model the effects of medical treatments (chelation and excision) on the reduction of doses. It was calculated that DTPA enhanced the urinary excretion, on average, by a factor of 17. The empirical analysis also allowed calculation of the efficacies of the medical treatments-excision and chelation averted approximately 76% and 5.5%, respectively, of the doses that would have been if there were no medical treatment. All bioassay data are provided in the appendix for independent analysis and to facilitate the compartmental modeling approaches being developed by the health physics community.
PMID: 33196522 [PubMed - in process]

Source: Health Physics - November 18, 2020 Category: Physics Authors: Poudel D, Klumpp JA, Bertelli L, Dumit S, Waters TL Tags: Health Phys Source Type: research