Oxycodone attenuates vascular leak and lung inflammation in a clinically relevant two-hit rat model of acute lung injury.

CONCLUSION: Oxycodone pretreatment appears to act via κ- and μ-opioid receptors to ameliorate LPS- and MV-induced lung injury by suppressing inflammation and apoptosis, and this protective effect might be mediated through the inhibition of the TLR4/NF-κB pathways.
PMID: 33187816 [PubMed - as supplied by publisher]

Source: Cytokine - November 10, 2020 Category: Molecular Biology Authors: Li X, Li R, Fang Q, Jamal M, Wang C, Wang Y, Zhang Z, Wu X, Song X Tags: Cytokine Source Type: research