Galleria mellonella as an experimental model for studying periodontopathogens

Thaís Aguiar Santos, Liliana Scorzoni, Aline de Castro Santos, Juliana Campos Junqueira, Ana Lia AnbinderJournal of Indian Society of Periodontology 2020 24(6):593-596 In the present study, Galleria mellonella was evaluated as a potential infection model for periodontal bacteria, more specifically, Porphyromonas gingivalis, Fusobacterium nucleatum, and Aggregatibacter actinomycetemcomitans. All the bacteria evaluated were pathogenic to G. mellonella, causing their death in a concentration-dependent manner, and a decrease in their hemocyte count. Moreover, it was possible to recover the bacteria from the larvae hemolymph and determine the colony-forming units per larvae. G. mellonella is an effective model that may help to better understand the host-microbe interactions in periodontics.
Source: Journal of Indian Society of Periodontology - Category: Dentistry Authors: Source Type: research