Shared and anxiety-specific pediatric psychopathology dimensions manifest distributed neural correlates

Imaging research has not yet delivered reliable psychiatric biomarkers. One challenge, particularly among youth, is high comorbidity. This challenge might be met through canonical correlation analysis (CCA) designed to model mutual dependencies between symptom dimensions and neural measures. We map the multivariate associations that intrinsic functional connectivity manifests with pediatric symptoms of anxiety, irritability, and attention-deficit/hyperactivity disorder (ADHD) as common, impactful, co-occurring problems.

Source: Biological Psychiatry - November 9, 2020 Category: Psychiatry Authors: Julia O. Linke, Rany Abend, Katharina Kircanski, Michal Clayton, Caitlin Stavish, Brenda E. Benson, Melissa A. Brotman, Olivier Renaud, Stephen M. Smith, Thomas E. Nichols, Ellen Leibenluft, Anderson M. Winkler, Daniel S. Pine Tags: Archival Report Source Type: research