Evaluation of Emotional Adverse Effects of Antidepressants: A Follow-up Study

Purpose/Background

Emotional adverse effects due to antidepressant use may cause difficulties for the clinician in the treatment of depression. In this prospective study, the emotional adverse effects of antidepressants were evaluated in various aspects.

Methods/Procedures

Ninety eight patients diagnosed with major depressive disorder were included in the study. At 2nd, 4th, 8th, 12th, and 16th weeks, patients were assessed with Montgomery-Asberg Depression Rating Scale (MADRS), and the antidepressant dose was increased in patients with less than a 50% reduction at each visit compared with the initial MADRS score. The Oxford Questionnaire on the Emotional Side-effects of Antidepressants (OQESA) was used at the 8th-week and 16th-week visits.

Findings/Results

A significant difference is found in the OQESA score at the 8th-week visit compared with the 16th-week assessment (P

Source: Journal of Clinical Psychopharmacology - November 1, 2020 Category: Psychiatry Tags: Original Contributions Source Type: research