Comparative analysis of differentially abundant proteins quantified by LC –MS/MS between flash frozen and laser microdissected OCT-embedded breast tumor samples

ConclusionsThe proteomic profiles of the OCT/LMD-TS samples were more similar to those from OCT/LMD-T samples than FF/HOM samples, suggesting a strong influence from the sample processing methods. These results indicate that in LC –MS/MS proteomic studies, FF/HOM samples exhibit different protein expression profiles from OCT/LMD samples and thus, results from these two different methods cannot be directly compared.

Source: Clinical Proteomics - November 7, 2020 Category: Biochemistry Source Type: research