LOTUS-domain proteins - developmental effectors from a molecular perspective.

LOTUS-domain proteins - developmental effectors from a molecular perspective. Biol Chem. 2020 Oct 01;: Authors: Kubíková J, Reinig R, Salgania HK, Jeske M Abstract The LOTUS domain (also known as OST-HTH) is a highly conserved protein domain found in a variety of bacteria and eukaryotes. In animals, the LOTUS domain is present in the proteins Oskar, TDRD5/Tejas, TDRD7/TRAP/Tapas, and MARF1/Limkain B1, all of which play essential roles in animal development, in particular during oogenesis and/or spermatogenesis. This review summarizes the diverse biological as well as molecular functions of LOTUS-domain proteins and discusses their roles as helicase effectors, posttranscriptional regulators, and critical co-factors of piRNA-mediated transcript silencing. PMID: 33098629 [PubMed - as supplied by publisher]
Source: Biological Chemistry - Category: Chemistry Tags: Biol Chem Source Type: research