Molecules, Vol. 25, Pages 4906: Recent Advances in Palladium-Catalyzed Isocyanide Insertions

Molecules, Vol. 25, Pages 4906: Recent Advances in Palladium-Catalyzed Isocyanide Insertions
Molecules doi: 10.3390/molecules25214906
Authors:
Jurriën W. Collet
Thomas R. Roose
Bram Weijers
Bert U. W. Maes
Eelco Ruijter
Romano V. A. Orru

Isocyanides have long been known as versatile chemical reagents in organic synthesis. Their ambivalent nature also allows them to function as a CO-substitute in palladium-catalyzed cross couplings. Over the past decades, isocyanides have emerged as practical and versatile C1 building blocks, whose inherent N-substitution allows for the rapid incorporation of nitrogeneous fragments in a wide variety of products. Recent developments in palladium catalyzed isocyanide insertion reactions have significantly expanded the scope and applicability of these imidoylative cross-couplings. This review highlights the advances made in this field over the past eight years.

Source: Molecules - October 23, 2020 Category: Chemistry Authors: Jurri ën W. Collet Thomas R. Roose Bram Weijers Bert U. W. Maes Eelco Ruijter Romano V. A. Orru Tags: Review Source Type: research