Spectrum of Myelinated Pulmonary Afferents (III) Cracking Intermediate Adapting Receptors.

Spectrum of Myelinated Pulmonary Afferents (III) Cracking Intermediate Adapting Receptors.
Am J Physiol Regul Integr Comp Physiol. 2020 Oct 21;:
Authors: Yu J
Abstract
Conventional one-sensor theory (one afferent fiber connects to a single sensor) categorizes the bronchopulmonary mechanosensors into the rapidly adapting receptors (RARs), slowly adapting receptors (SARs), or intermediate adapting receptors (IARs). RARs and SARs are known to sense the rate and magnitude of mechanical change, respectively; however, there is no agreement on what IARs sense. Some investigators believe the three types of sensors are actually one group with similar but different properties and IARs operate within that group. Other investigators (majority) believe IARs overlap with the RARs and SARs and can be classified within them according to their characteristics. Clearly, there is no consensus on IARs function. Recently a multiple-sensor theory has been advanced in which a sensory unit may contain many heterogeneous sensors, such as both RARs and SARs. There are no IARs. Intermediate adapting unit behavior results from co-existence of RARs and SARs. Therefore, the unit can sense both rate and magnitude of changes. The purpose of this review is to provide evidence that the multiple-sensor theory better explains sensory unit behavior.
PMID: 33085910 [PubMed - as supplied by publisher]

Source: American Journal of Physiology. Regulatory, Integrative and Comparative Physiology - October 21, 2020 Category: Physiology Authors: Yu J Tags: Am J Physiol Regul Integr Comp Physiol Source Type: research