New mouse model of underactive bladder developed by placement of a metal ring around the bladder neck

ConclusionsWe successfully established a novel mouse model of UAB using surgery to place a silver jump ring loosely on the bladder neck. BOO initially induced bladder overactivity but subsequently resulted in UAB due to deterioration of detrusor smooth muscle contractility and progressive deposition of collagen in the bladder wall.

Source: LUTS: Lower Urinary Tract Symptoms - October 21, 2020 Category: Urology & Nephrology Authors: Kareman Eljamal, Shunichi Kajioka, Tomoko Maki, Miho Ushijima, Kentaro Kawagoe, Ken Lee, Toshiyuki Sasaguri Tags: ORIGINAL ARTICLE Source Type: research