Favipiravir for COVID-19 in a Patient on Hemodialysis

Publication date: Available online 1 October 2020Source: American Journal of Kidney DiseasesAuthor(s): Daisuke Hirai, Daisuke Yamashita, Koichi Seta
Source: American Journal of Kidney Diseases - Category: Urology & Nephrology Source Type: research

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Hydroxychloroquine (HQ) has been used for the treatment of novel coronavirus disease (COVID-19) even though there is no clear evidence for its effectiveness yet. In contrary, HQ has major side effects like QTc prolongation and subsequent development of ventricular arrhythmias. Such side effects may possess additional risks on end-stage renal disease (ESRD) patients who have higher cardiovascular risks than general population. We herein present 2 cases of sudden cardiac death in 2 ESRD patients with COVID-19 for whom a treatment regimen including HQ was preferred. Both patients were clinically stable at the time of arrest. ...
Source: Blood Purification - Category: Hematology Source Type: research
Treatment of COVID-19 atypical pneumonia by early Tocilizumab administration in "non-critically-ill" patients on hemodialysis. J Nephrol. 2020 Sep 30;: Authors: Castellano G, Infante B, Mercuri S, Forcella M, Cox SN, Serviddio G, Gesualdo L, Stallone G PMID: 32997331 [PubMed - as supplied by publisher]
Source: Journal of Nephrology - Category: Urology & Nephrology Authors: Tags: J Nephrol Source Type: research
Authors: Deshpande R, Dash S, Bahadur MM, Thamba A, Pathan AK, Dave K, Chaudhari C, Shringare A, Patil A Abstract COVID-19 has emerged as a pandemic of significance with potential to cause significant morbidity and mortality worldwide. Elderly with or without following comorbidities i.e Diabetes, hypertension, cardiac disease, chronic respiratory illnesses, chronic liver disease, CKD, malignancy and immunocompromised hosts are at increased risk of developing complicated course. Hemodialysis population hence are at increased risk for contracting the infection due to patient characteristics, environmental characteris...
Source: Journal of the Association of Physicians of India - Category: General Medicine Tags: J Assoc Physicians India Source Type: research
CONCLUSION: COVID-19 infection is associated with increased mortalit in chronic kidney diseases patients. Despite being non-significant, there was a trend towards increased mortality in patient with diabetes, D-dimer levels>1000 ugFEU/L and higher ferritin, prokalsitonin levels, increased CRP/albumin raio and lower neutrophil/lymphocyte ratio. PMID: 32950045 [PubMed - as supplied by publisher]
Source: Turkish Journal of Medical Sciences - Category: General Medicine Tags: Turk J Med Sci Source Type: research
Source: Infectious Diseases - Category: Infectious Diseases Authors: Source Type: research
Authors: Ossareh S, Bagheri M, Abbasi M, Abolfathi S, Bohlooli A Abstract INTRODUCTION: Seven months after the emergence of SARS-COV-2 virus, there is paucity of data regarding the epidemiology of the virus in hemodialysis patients. We aim to present the results of the screening program implied after outbreak of COVID-19 in a referral hemodialysis ward. METHODS: We started clinical screening and obligatory mask wearing for dialysis patients and personnel on 20-Feb-2020. However 11 symptomatic COVID-19 patients emerged till day +36. On days +39 and +40 a screening program was implied including measurement of SAR...
Source: Iranian Journal of Kidney Diseases - Category: Urology & Nephrology Tags: Iran J Kidney Dis Source Type: research
AbstractPurposeThis present study aims to investigate the relationship between laboratory parameters on admission and prognosis of coronavirus disease 2019 (COVID-19) in maintenance hemodialysis patients, as well as providing a theoretical basis for clinical evaluation of prognosis and corresponding intervention measures.MethodsRetrospective analysis was performed on the clinical data of 47 maintenance hemodialysis patients who infected with COVID-19 and admitted to our hospital. According to their clinical outcome, these patients were divided into a survival group (n = 38) and a fatality group (n =&th...
Source: International Urology and Nephrology - Category: Urology & Nephrology Source Type: research
Authors: Herrera-Añazco P, Rabanal CL, Benites-Zapata VA PMID: 32941592 [PubMed - as supplied by publisher]
Source: Jornal Brasileiro de Nefrologia - Category: Urology & Nephrology Tags: J Bras Nefrol Source Type: research
We read with great interest the recently published study by Wright and colleagues,1 in which the authors have investigated the prognostic value of thromboelastography (TEG) measurements of coagulation in patients with COVID-19 admitted to the ICU. Despite the retrospective nature of the study and the low sample size, the authors have interestingly shown that fibrinolysis shutdown, as evidenced by elevated D-Dimer and complete failure of clot lysis at 30 minutes on TEG, predicted thromboembolic events and need for hemodialysis in these patients.
Source: Journal of the American College of Surgeons - Category: Surgery Authors: Tags: Letter Source Type: research
The COVID-19 pandemic has proven to have significant morbidity and mortality in high risk patient populations including those with cancer. Chronic lymphocytic leukemia (CLL) is an indolent disease and the majority of patients with CLL are under monitoring. Here we present a case of a CLL patient with severe COVID-19 presenting with marked lymphocytosis within 2-3 days of diagnosis. An 80-years old man with treatment na ïve CLL was admitted to our hospital for COVID-19 pneumonia. He was intubated due to hypoxic respiratory failure and developed multi-system organ failure requiring hemodialysis and vasopressor therapy.
Source: Clinical Lymphoma, Myeloma and Leukemia - Category: Hematology Authors: Tags: Case Report Source Type: research
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