Cell-Autonomous versus Systemic Akt Isoform Deletions Uncovered New Roles for Akt1 and Akt2 in Breast Cancer

Chen et  al. find that inducible systemic Akt1 deletion after tumor detection inhibits breast cancer metastasis of Akt-proficient tumor by inhibiting tumor-associated neutrophils. Inducible systemic Akt2 deletion does not inhibit breast cancer tumorigenesis and metastasis. Thus, specific Akt1 inhibition co uld be therapeutic for breast cancer metastasis regardless of tumor origin.

Source: Molecular Cell - September 13, 2020 Category: Cytology Authors: Xinyu Chen, Majd M. Ariss, Gopalakrishnan Ramakrishnan, Veronique Nogueira, Catherine Blaha, William Putzbach, Abul B.M.M.K. Islam, Maxim V. Frolov, Nissim Hay Tags: Article Source Type: research