Analysis of angiogenic and stromal biomarkers in a large malignant mesothelioma cohort

Angiogenesis is a complex process involving the interaction between tumour cells, growth factors and cells within the tumour microenvironment (TME). The purported primary stimulus for angiogenesis in the TME is the hypoxia-driven activation of hypoxia-inducible factor-1 α, and the subsequent activation of VEGF, along with many other growth factors including platelet derived growth factors, endothelial growth factors and fibroblast growth factor.1–3 The interaction between these cells within the TME and the supporting growth factors induce pro-inflammatory mediat ors which supports proliferation and survival of malignant cells, stromal remodelling and propagates angiogenesis-related factors.

Source: Lung Cancer - September 29, 2020 Category: Cancer & Oncology Authors: Puey Ling Chia, Prudence Russell, Khashi Asadi, Bibhusal Thapa, Val Gebski, Carmel Murone, Marzena Walkiewicz, Ulf Eriksson, Andrew M. Scott, Thomas John Source Type: research