Muscle imaging – mri

Quantitative ultrasound (qUS) is an objective, painless, and cost-effective modality that can distinguish healthy from damaged muscle. The cardinal feature of abnormal muscle on qUS is increased echointensity (EI). Increased EI has been demonstrated in humans with DMD and in the mdx mouse model; however, it remains to be determined if the pattern of increased EI is similar in all muscular disorders. We compared qUS images from two disease models that impact muscle in dissimilar ways: the D2-mdx mouse, a model of DMD characterized by increased fibrosis, and the db/db diabetic obese mouse, known to develop muscle atrophy and excessive fat deposition.

Source: Neuromuscular Disorders - September 28, 2020 Category: Neurology Authors: S. Chrzanowski, A. Pigula Tresansky, J. Nagy, S. Rutkove, B. Anthony Source Type: research