A potential for seamless designs in diagnostic research could be identified.

New diagnostic tests to identify a well-established disease state must undergo a series of scientific studies from test construction to finally demonstrating a societal impact. Traditionally, these studies are performed with substantial time gaps in between, resulting in a long time period from the initial idea to roll out in clinical practice including reimbursement. Seamless designs allowing us to combine a sequence of studies in one protocol may hence accelerate this process. Currently, a systematic investigation of the potential of seamless designs in diagnostic research is lacking.

Source: Journal of Clinical Epidemiology - September 25, 2020 Category: Epidemiology Authors: Vach W, E. Bibiza, O. Gerke, P.M. Bossuyt, T. Friede, A. Zapf Tags: Original Article Source Type: research