Absolute Bioavailability of Microdosed Midazolam After Buccal Administration Is Dependent on Buccal Exposure Time.
In conclusion, midazolam bioavailability is highly dependent on buccal exposure time, and even a few seconds of buccal exposure will increase bioavailability due to buccal absorption. This needs to be taken into account for any buccal administration of midazolam.
PMID: 32976642 [PubMed - as supplied by publisher]
Source: The Journal of Clinical Pharmacology - Category: Drugs & Pharmacology Authors: Grass J, Rose P, Burhenne J, Blank A, Haefeli WE, Mikus G Tags: J Clin Pharmacol Source Type: research
More News: Clinical Trials | Drugs & Pharmacology