Bixin Action in the Healing Process of Rats Mouth Wounds.

Bixin Action in the Healing Process of Rats Mouth Wounds.
Curr Pharm Biotechnol. 2013 Dec 26;
Authors: Piva RM, Rodrigues Johann AC, Costa CK, Miguel OG, Rosa ER, de Azevedo-Alanis LR, Trevilatto PC, Ignácio SA, Cassi Bettega PV, Grégio AM
Abstract
Oral lesions that manifest as ulcer lesions are quite common and can cause discomfort to the patient. Searching for drugs to accelerate the healing of these lesions is nonstop process. Bixin is a molecule found in annatto (urucum) seeds and is considered a viable therapeutic option to treat such lesions due to its anti-inflammatory, anti-oxidant, and healing properties. Therefore, the present study aimed to evaluate the effect of the bixin solution in the ulcer healing process in the oral mucosa of rats. Ulcers were induced with punches of 0.5 cm in the middle of the dorsum of the tongue of 64 Wistar rats. The animals were randomly divided into 8 groups, in which 4 groups were treated with saline solution, while the other 4 were treated with the bixin solution. The animals were sacrificed in the periods 2, 7, 14, and 21 days after the beginning of the treatment. The species were histologically processed and stained with hematoxylin/eosin and picrosirius. Fibroblasts, reepithelialization, and wound contraction could be observed, as could the quantification of neutrophils, macrophages, plasma cells, lymphocytes, and mature and immature collagen. On the seventh day, the experimental group, when compa...

Source: Current Pharmaceutical Biotechnology - December 26, 2013 Category: Biotechnology Authors: Piva RM, Rodrigues Johann AC, Costa CK, Miguel OG, Rosa ER, de Azevedo-Alanis LR, Trevilatto PC, Ignácio SA, Cassi Bettega PV, Grégio AM Tags: Curr Pharm Biotechnol Source Type: research