Inter-fraction motion robustness and organ sparing potential of proton therapy for cervical cancer
One out of thirty cancer patients worldwide is diagnosed with cervical cancer  and the 5-year overall survival rate for the early stage group is 91% . Half of all diagnosed cervical cancer patients is younger than 35 years , whereby late radiation-induced toxicities have a large influence on quality of life . Thus, prevention of late radiation-induced side effects becomes increasingly relevant.
CONCLUSION: Robustly optimized PBS-PT for cervical cancer patients shows equivalent target robustness against inter- and intra-fraction variability compared to VMAT, and offers significantly better OAR sparing. PMID: 32956707 [PubMed - as supplied by publisher]
Both plan quality and robustness were investigated through comparing some dosimetric metrics between intensity modulated proton therapy (IMPT) and helical tomotherapy based intensity modulated radiotherapy (IM...
Conclusion: The automated prior-plan adaptation method can successfully adapt for the large day-to-day variations observed in cervical cancer patients. PMID: 31271076 [PubMed - as supplied by publisher]
ConclusionsIn patients with cervical cancer, both proton therapy and MRI-based target tailoring lead to a significant reduction in the dose to surrounding organs at risk and small bowel toxicity.
CONCLUSION: Bowel gas cavities and outline variations had minor impact on accumulated dose in targets and OAR of four-field IMPT in a LACC population of moderate weight changes. PMID: 28931343 [PubMed - as supplied by publisher]
The aim of this study was to compare the dosimetric parameters of whole-pelvic radiotherapy (WPRT) for cervical cancer among plans involving 3D conformal radiotherapy (3D-CRT), intensity-modulated radiotherapy (IMRT), or spot-scanning proton therapy (SSPT). The dose distributions of 3D-CRT-, IMRT-, and SSPT-based WPRT plans were compared in 10 patients with cervical cancer. All of the patients were treated with a prescribed dose of 50.4 Gy in 1.8-Gy daily fractions, and all of the plans involved the same planning target volume (PTV) constrictions. A 3D-CRT plan involving a four-field box, an IMRT plan involving seven copla...
Conclusions ADT should be considered as a therapeutic option for unresectable advanced SDC.
Whole pelvic radiation therapy (WPRT) plays an important role in the treatment of gynecologic cancers, especially cervical and endometrial cancers. Conventional WPRT contains approximately 40% of the total body bone marrow (BM) and results in hematologic toxicity (HT) . Concurrent chemoradiotherapy (CCRT) is used to improve treatment outcome. However, adding chemotherapy increases the risk of severe HT. Severe HT is critical issue because it disturbs the execution of treatment on schedule such as interruptions of radiotherapy and holds or stops chemotherapy .
In this dosimetric comparison study it was shown that IMPT with robust planning reduces dose to surrounding organs in cervical and endometrial cancer treatment compared with IMRT. Especially for the para-aortic region, clinically relevant dose reductions were obtained for kidneys, spinal cord and bowel, justifying the use of proton therapy for this indication.
ConclusionPT for PHL showed no short‐term severe toxicity and yields similar short‐term control to recently published large multi‐institutional clinical trials.