DNA Damage Promotes TMPRSS2-ERG Oncoprotein Destruction and Prostate Cancer Suppression via Signaling Converged by GSK3 β and WEE1

TMPRSS2-ERG oncoprotein plays a pivotal role in prostate oncogenesis and progression and is a potential therapeutic target of prostate cancer. Hong et  al. reveal a previously unrecognized TMPRSS2-ERG protein destruction mechanism, and intact PTEN and GSK3β signaling are essential for effective targeting of TMPRSS2-ERG by genotoxic therapeutics in prostate cancer.

Source: Molecular Cell - August 30, 2020 Category: Cytology Authors: Zhe Hong, Wei Zhang, Donglin Ding, Zhenlin Huang, Yuqian Yan, William Cao, Yunqian Pan, Xiaonan Hou, Saravut J. Weroha, R. Jeffrey Karnes, Dejie Wang, Qiang Wu, Denglong Wu, Haojie Huang Tags: Article Source Type: research