Functional Interplay between Histone H2B ADP-Ribosylation and Phosphorylation Controls Adipogenesis

Huang et  al. show that the nuclear NAD+ synthase, NMNAT-1, directs PARP-1 catalytic activity to Glu and Asp residues on histones. Physiological ADP-ribosylation of histone H2B-Glu35 by snoRNA-activated PARP-1 with NMNAT-1 inhibits AMPK-mediated phosphorylation of adjacent H2B-Ser36, which is required for p roadipogenic gene expression and fat metabolism in vivo.

Source: Molecular Cell - August 19, 2020 Category: Cytology Authors: Dan Huang, Cristel V. Camacho, Rohit Setlem, Keun Woo Ryu, Balaji Parameswaran, Rana K. Gupta, W. Lee Kraus Tags: Article Source Type: research