PARP-1 Flips the Epigenetic Switch on Obesity

PARP enzymes are increasingly taking on important roles beyond DNA repair. Huang et  al. (2020b) report how the NAD+-dependent ADP-ribosylation of histone H2B by PARP-1 in complex with a metabolic enzyme suppress the phosphorylation of an adjacent residue, impacting adipogenesis.
Source: Molecular Cell - Category: Cytology Authors: Tags: Preview Source Type: research