Patients with benign prostatic hyperplasia show shorter leukocyte telomere length but no association with telomerase gene polymorphisms in Han Chinese males.

CONCLUSIONS: Shorter telomeres but not telomerase SNPs at the TERT and TERC loci, are associated with BPH. Short telomeres may promote senescence of a fraction of prostatic epithelial cells, while senescent cells in turn facilitate epithelial and stromal cell proliferation by the senescence-associated secretory phenotype mechanism, thereby eventually leading to BPH development.
PMID: 32922609 [PubMed]

Source: International Journal of Clinical and Experimental Pathology - September 15, 2020 Category: Pathology Authors: Cheng G, Dai M, Xin Q, Wang L, Kong F, Xu D Tags: Int J Clin Exp Pathol Source Type: research