Two new diterpenoids from Penicillium chrysogenum MT-12, an endophytic fungus isolated from Huperzia serrata.

Two new diterpenoids from Penicillium chrysogenum MT-12, an endophytic fungus isolated from Huperzia serrata.
Nat Prod Res. 2020 Aug 25;:1-8
Authors: Qi B, Jia F, Luo Y, Ding N, Li S, Shi F, Hai Y, Wang L, Zhu ZX, Liu X, Tu P, Shi SP
Abstract
Two new diterpenoids, penicichrysogene A (1) and penicichrysogene B (2), were isolated from the solid substrate fermentation cultures of Penicillium chrysogenum MT-12, an endophytic fungus isolated from the medicinal plant of Huperzia serrata. Their structures were elucidated on the basis of extensive spectroscopic and spectrometric data (1D and 2D NMR, UV, IR, and HRESIMS). The absolute configurations of 1 and 2 were assigned on the basis of experimental and calculated electronic circular dichroism spectra. Compound 1 exhibited inhibitory activity on ATP release of thrombin-activated platelets with IC50 = 42.7 ± 3.5 μM.
PMID: 32840396 [PubMed - as supplied by publisher]

Source: Natural Product Research - August 24, 2020 Category: Biochemistry Authors: Qi B, Jia F, Luo Y, Ding N, Li S, Shi F, Hai Y, Wang L, Zhu ZX, Liu X, Tu P, Shi SP Tags: Nat Prod Res Source Type: research