Induction of thoracic aortic dissection: a mini-review of β-aminopropionitrile-related mouse models.

Induction of thoracic aortic dissection: a mini-review of β-aminopropionitrile-related mouse models.
J Zhejiang Univ Sci B. 2020 Aug.;21(8):603-610
Authors: Zheng HQ, Rong JB, Ye FM, Xu YC, Lu HS, Wang JA
Abstract
Thoracic aortic dissection (TAD) is one of the most lethal aortic diseases due to its acute onset, rapid progress, and high rate of aortic rupture. The pathogenesis of TAD is not completely understood. In this mini-review, we introduce three emerging experimental mouse TAD models using β-aminopropionitrile (BAPN) alone, BAPN for a prolonged duration (four weeks) and then with added infusion of angiotensin II (AngII), or co-administration of BAPN and AngII chronically. We aim to provide insights into appropriate application of these three mouse models, thereby enhancing the understanding of the molecular mechanisms of TAD.
PMID: 32748576 [PubMed - in process]

Source: J Zhejiang Univ Sci ... - July 31, 2020 Category: Science Authors: Zheng HQ, Rong JB, Ye FM, Xu YC, Lu HS, Wang JA Tags: J Zhejiang Univ Sci B Source Type: research