Immunostimulation with chemotherapy in the era of immune checkpoint inhibitors

Nature Reviews Clinical Oncology, Published online: 05 August 2020; doi:10.1038/s41571-020-0413-zThe efficacy of chemotherapy in patients with cancer is now known to have an immunogenic component. Nonetheless, chemotherapy alone often fails to provide durable disease remission in most patients. The development of immune checkpoint inhibitors has created an opportunity to combine immunogenic chemotherapies with these agents in order to optimize patient outcomes. In this Review, the authors describe the mechanisms of synergy between chemotherapy and immune checkpoint inhibitors, summarize the available clinical data on these effects and highlight the most promising areas for future research.
Source: Nature Reviews Clinical Oncology - Category: Cancer & Oncology Authors: Source Type: research