Expression of α-Klotho is downregulated and associated with oxidative stress in the lens in streptozotocin-induced diabetic rats.

Conclusions: These findings suggest that DM selectively reduces α-Klotho levels in the circulation and lens, which may attenuate transcriptional activity of Nrf2 and impair antioxidant defenses in response to oxidative insults, contributing to oxidative stress and cataract formation in DM. PMID: 32744464 [PubMed - as supplied by publisher]

https://www.ncbi.nlm.nih.gov/pubmed/32744464?dopt=Abstract

Source: Current Eye Research - August 2, 2020 Category: Opthalmology Authors: Ma Z, Li J, Jiang H, Chu Y Tags: Curr Eye Res Source Type: research