Low-Frequency (20 kHz) Ultrasonic Modulation of Drug Action

We tested the effect of low-frequency ultrasound (LUS, 20 kHz, 4 W/cm2) on the function of rat mesentery and human pulmonary arteries with wire myography. The vessels were induced to contract with either noradrenaline or physiologic saline solution (PSS) with a high potassium concentration (KPSS) and then incubated with capsaicin (2.1  × 10–7 M, TRPV1 [transient receptor potential vanilloid 1] activator), dopamine (1 × 10–4 M, dopamine and α2-receptor activator), or fenoldopam (dopamineA1 receptor agonist, 1 × 10–4 M) with and without glibenclamide (1 μM, KATP [adenosine triphosphate {sensitive potassium ch annel (ATP)}-sensitive potassium channel] inhibitor and α2-receptor modulator), and insonated.
Source: Ultrasound in Medicine and Biology - Category: Radiology Authors: Tags: Original Contribution Source Type: research